@article{101036,
  keywords = {Wound Healing, Calotrope (Calotropis procera), Hanseniasis, Latex},
  author = {Nunes MO and Alencar NMN and Pontes MAA and Silva PGB and Rabelo LMA and Lima-Filho JV and Souza TFG and Almeida MGG and Ramos MV},
  title = {Healing of leprosy-associated chronic plantar wounds with a novel biomembrane containing latex proteins from Calotropis procera},
  abstract = {<p>Pre-clinical assays demonstrated that a 1% polyvinyl alcohol biomembrane containing latex proteins (10%) from the medicinal plant Calotropis procera was biocompatible and stimulated healing of incisional and excisional wounds in murine models, and the mechanistic aspects were established. The efficacy of the biomembrane (BioMemCpLP) to promote healing of chronic ulcers in leprosy patients was investigated. The study started with 28 volunteers. Five were excluded later due to different disconformities. Ulcers from 15 patients were continuously treated with BioMemCpLP for 56 days. Five patients were treated only with silver sulfadiazine and three patients received plain hydrocolloid wound dressings with high absorption capacity. In all cases, wound dressings were renewed three times a week for 56 days and ulcers were evaluated weekly for contraction and healing progress. The extent of the healed area in the ulcers treated with BioMemCpLP was greater than in the control groups. Approximately 88% of ulcers treated with BioMemCpLP were fully healed before day 56, against 6% in both control groups. This result was not correlated with age/gender, duration or location of ulcers, deformity or whether or not the patient was cured of leprosy. The results showed that BioMemCpLP was beneficial for treatment of ulcers suffered by leprosy patients without noticeable side effects.</p>
},
  year = {2024},
  journal = {Brazilian Journal of Biology},
  volume = {84},
  pages = {1-11},
  publisher = {FapUNIFESP (SciELO)},
  issn = {1678-4375, 1519-6984},
  url = {https://www.scielo.br/j/bjb/a/pptDFyPbb3wcsptpZ3CbRDG/?format=pdf&lang=en},
  doi = {10.1590/1519-6984.281674},
  language = {ENG},
}