@article{101621, keywords = {Sweet Syndrome, Dermatopathology, Erythema Nodosum Leprosum}, author = {Sidhom S and Yang E and Gowda A and Kim L and Robinson-Bostom L and Massoud C}, title = {Atypical Type 2 Lepra Reaction Masquerading as Recurrent Sweet Syndrome.}, abstract = {

Erythema nodosum leprosum (ENL) is an immune complex-mediated response in Mycobacterium leprae infection, presenting with fever, arthralgias, and tender cutaneous lesions. It mimics Sweet syndrome (SS) clinically and histologically but requires distinct management. A 65-year-old man with recent travel presented with fever and edematous plaques. Initial findings supported SS, improving with corticosteroids. Symptom recurrence and a contact's leprosy diagnosis led to further testing, revealing M. leprae through repeat staining and tissue PCR. This case underscores the need to consider ENL in Sweet-like cases with relevant travel history. Repeat staining and molecular testing are essential for accurate diagnosis and treatment.

}, year = {2024}, journal = {Journal of cutaneous pathology}, month = {12/2024}, issn = {1600-0560}, doi = {10.1111/cup.14762}, language = {ENG}, }