@article{101690,
  keywords = {IgG seropositivity, Leishmaniasis, leprosy, Parasitic co-infections, Toxoplasmosis},
  author = {de Oliveira A and Brito R and Siqueira W and de Jesus A and Bueno L and Fujiwara R},
  title = {IgG seroprevalence of Toxoplasma gondii and Leishmania infantum in leprosy patients: Implications for screening and management of co-infections.},
  abstract = {<p>Parasitic co-infections are common in developing countries and can interfere with leprosy treatment, leading to an increased risk of inflammatory leprosy reactions. This study assessed serum immunoglobulin G (IgG) levels against Toxoplasma gondii and Visceral Leishmaniasis (VL) antigens in 270 leprosy patients from Brazilian states. Regarding the respective cut-offs, the prevalence of IgG seropositivity for T. gondii and VL were 21.05 % and 47.36 % in the leprosy-negative group, and 77.7 % and 52.6 % in the leprosy-positive group. Of the 270 leprosy patients, 158 (58.5 %) presented with inflammatory leprosy reactions. Of those, 72 (59.5 %) had neuritis, 35 (48.6 %) had reverse reactions, and 28 (38.9 %) had ENL in both Brazilian states. Leprosy patients with anti-Leishmania IgG seropositivity were 3.25 times more likely to develop neuritis (95 % C.I.: 1.187 - 9.154; p = 0.019). These findings are particularly relevant for clinical settings where both leprosy and parasitic diseases are prevalent and could provide essential guidance for detecting and addressing complications arising from parasitic co-infections in leprosy patients, thereby improving clinical management strategies.</p>},
  year = {2024},
  journal = {Diagnostic microbiology and infectious disease},
  volume = {110},
  month = {09/2024},
  issn = {1879-0070},
  doi = {10.1016/j.diagmicrobio.2024.116405},
  language = {ENG},
}