@article{10274,
  keywords = {Animals, Antigens, Bacterial, Chemical Fractionation, Female, Humans, In Vitro Techniques, leprosy, Lymphocyte Activation, Macaca mulatta, Male, Monocytes, Mycobacterium leprae, Receptors, Fc, T-Lymphocytes, Regulatory},
  author = {Ohkawa S and Martin L N and Fukunishi Y and Gormus B J},
  title = {Regulatory role of FcR+ and FcR- monocyte subsets in Mycobacterium leprae-induced lymphoproliferative response in vitro.},
  abstract = {<p>We investigated nine rhesus monkeys (Macaca mulatta) inoculated with Mycobacterium leprae and three normal human contacts. Peripheral blood monocytes were separated into Fc receptor positive (FcR+) and Fc receptor negative (FcR-) fractions, and their regulatory role in the lymphoproliferative response in vitro to M. leprae was studied. FcR- monocytes had strong antigen presentation activity and produced no suppressor effect while FcR+ monocytes had weak antigen presentation activity and produced a non-specific suppressor factor spontaneously. With this assay system we determined that M. leprae-inoculated rhesus monkeys could be divided into three groups: good responders, very weak responders, and non-responders.</p>},
  year = {1987},
  journal = {Clinical and experimental immunology},
  volume = {67},
  pages = {43-50},
  month = {1987 Jan},
  issn = {0009-9104},
  url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1542573/pdf/clinexpimmunol00112-0052.pdf},
  language = {eng},
}