@article{1494,
  keywords = {Antibodies, Antibody Specificity, Apoptosis, CD28 Antigens, Cells, Cultured, Cytokines, Humans, Interleukin-1, Interleukin-6, Ionomycin, leprosy, Leukocytes, Mononuclear, Tumor Necrosis Factor-alpha, Zinc},
  author = {Gupta A and Sharma V K and Vohra H and Ganguly N K},
  title = {Spontaneous apoptosis in peripheral blood mononuclear cells of leprosy patients: role of cytokines.},
  abstract = {<p>Peripheral blood mononuclear cells from leprosy patients underwent spontaneous apoptosis upon culture for 24 h. The apoptosis was inhibited by anti-TNFalpha antibodies and to a certain extent by anti-IL-1alpha and IL-6, thus showing that T(H)2-type cytokines (mainly TNFalpha) are responsible for inducing apoptosis. This cytokine-mediated apoptosis could be inhibited by ionomycin and zinc, thereby suggesting that these metal ions can be used to decrease the levels of these inflammatory cytokines in various diseases.</p>},
  year = {1999},
  journal = {FEMS immunology and medical microbiology},
  volume = {24},
  pages = {49-55},
  month = {1999 May},
  issn = {0928-8244},
  doi = {10.1111/j.1574-695X.1999.tb01264.x},
  language = {eng},
}