@article{15324,
  keywords = {Adolescent, Adult, Africa, Age Factors, Aged, Carcinoma, Hepatocellular, Child, Child, Preschool, Ethnic Groups, Female, Hepatitis B, Hepatitis B Antibodies, Hepatitis B Antigens, Hepatitis B virus, Hepatomegaly, Humans, Infant, Liver Neoplasms, Male, Middle Aged, Senegal, Alpha-Fetoproteins},
  author = {Coursaget P and Maupas P and Goudeau A and Chiron J P and Drucker J and Denis F and Diop-Mar I},
  title = {Primary hepatocellular carcinoma in intertropical Africa: relationship between age and hepatitis B virus etiology.},
  abstract = {<p>Clinical observations of patients with primary hepatocellular carcinoma (PHC) at Le Dantec Hospital, Dakar, Senegal, were studied to determine a correlation with hepatitis B virus (HBV) infection. Of the 103 patients with PHC, 80 had an active HBV infection (HBsAg and/or anti-HBc); 23 showed signs of previous HBV infection (anti-HBs and anti-HBc). The two groups were similar in the detection of alpha-fetoprotein (approximately 60%) and in the major clinical findings: hepatomegaly, 76.25% and 86.96%, respectively; and ascites, 57.50% and 47.83%, respectively. Jaundice, however, was three times more frequent (P < 0.01) in the group of patients with signs of active HBV replication. Distribution of HBV markers as a function of age at onset of PHC revealed that the presence of HBsAg was primarily confined to the sera of the younger patients (< 50 yr old). When compared with leprosy patients and blood donors, the younger PHC patients differed in the frequency of detection of HBsAg and anti-HBs. The older people (> 50 yr old) in the three groups (PHC patients, leprosy patients, and blood donors) had identical HBV markers.</p>},
  year = {1980},
  journal = {Journal of the National Cancer Institute},
  volume = {65},
  pages = {687-90},
  month = {1980 Oct},
  issn = {0027-8874},
  doi = {10.1093/jnci/65.4.687},
  language = {eng},
}