@article{16181, keywords = {Adult, Dapsone, Drug Resistance, Microbial, Eyelid Diseases, Female, Humans, Iris Diseases, leprosy, Male, Tissue Adhesions}, author = {Brandt F and Adiga R B and Pradhan H}, title = {[Lagophthalmos and posterior synechiae of the iris during treatment of leprosy with diaminodiphenylsulfone].}, abstract = {

Four years after controlled and standardized chemotherapy with diaminodiphenylsulfone (DDS), 316 patients in the leprosarium at Khokana, Nepal were re-examined for ophthalmological findings. Patients who, 4 years earlier, had not had lagophthalmos in either eye, nor posterior synechiae of the iris, had only developed these complications in the meantime if they were suffering from DDS-resistant leprosy. New posterior synechiae of the iris were only found in patients with inactive leprosy who had already had a posterior synechia in the fellow eye four years previously. In cases of inactive leprosy there was also a tendency for existing posterior synechiae to increase. It is emphasized that the development of lagophthalmos or posterior synechiae of the iris indicates that a previously inactive leprosy may have become reactivated in spite of treatment with DDS.

}, year = {1984}, journal = {Klinische Monatsblatter fur Augenheilkunde}, volume = {184}, pages = {28-31}, month = {1984 Jan}, issn = {0023-2165}, doi = {10.1055/s-2008-1054403}, language = {ger}, }