@article{19269,
  keywords = {Alleles, Carrier Proteins, Cation Transport Proteins, Genetic Markers, Genetic Predisposition to Disease, Haplotypes, Host-Parasite Interactions, Humans, leprosy, Membrane Proteins, Pedigree, Polymorphism, Genetic},
  author = {Abel L and Sanchez F O and Oberti J and Thuc N V and Hoa L V and Lap V D and Skamene E and Lagrange P H and Schurr E},
  title = {Susceptibility to leprosy is linked to the human NRAMP1 gene.},
  abstract = {<p>Leprosy is a debilitating infectious disease of human skin and nerves. Genetic factors of the host play an important role in the manifestation of disease susceptibility. The human NRAMP1 gene is a leprosy susceptibility candidate locus since its murine homologue Nramp1 (formerly Lsh/Ity/Bcg) controls innate resistance to Mycobacterium lepraemurium. In this study, 168 members of 20 multiplex leprosy families were genotyped for NRAMP1 alleles and 4 closely linked polymorphic markers. Highly informative haplotypes overlapping the NRAMP1 gene were constructed, and the haplotype segregation into leprosy-affected offspring was analyzed. It was observed that the segregation of NRAMP1 haplotypes into affected siblings was significantly nonrandom. This finding is consistent with the hypothesis that NRAMP1 itself is a leprosy susceptibility locus.</p>},
  year = {1998},
  journal = {The Journal of infectious diseases},
  volume = {177},
  pages = {133-45},
  month = {1998 Jan},
  issn = {0022-1899},
  doi = {10.1086/513830},
  language = {eng},
}