@article{23207,
  keywords = {Adult, Aged, Alleles, Cytochrome P-450 CYP2E1, Female, Genetic Predisposition to Disease, genotype, Glutathione Transferase, Humans, leprosy, Male, Middle Aged, Polymorphism, Single Nucleotide, Risk Factors},
  author = {Pinto P and Salgado CG and Santos N and Alencar D and Santos S and Hutz M and Ribeiro-Dos-Santos A},
  title = {Polymorphisms in the CYP2E1 and GSTM1 genes as possible protection factors for leprosy patients.},
  abstract = {<p><b>BACKGROUND: </b>The CYP2E1 and GSTM1 genes encode metabolic enzymes that have key functions in drug modification and elimination.</p><p><b>METHODOLOGY/PRINCIPAL FINDINGS: </b>We investigated the possible effects of CYP2E1 and GSTM1 polymorphisms in 71 leprosy patients and in 110 individuals from the general population. The GSTM1*0 null allele and INDEL CYP2E1*1D mutant genotypes were analyzed by conventional PCR, while CYP2E1 SNPs (1053C>T, 1293G>C and 7632T>A) were determined by RT-PCR. In leprosy patients, the GSTM1*0 and CYP2E1*5 alleles and the combined alleles GSTM1*0/CYP2E1*6 and GSTM1*0/CYP2E1*5 were significantly related to a baciloscopic index (BI) (BI<3), while the CYP2E1*6 allele was related to a better clinical evolution in the leprosy spectrum.</p><p><b>CONCLUSIONS/SIGNIFICANCE: </b>Therefore, GSTM1*0, CYP2E1*5 and CYP2E1*6 may be possible protection factors for leprosy patients.</p>},
  year = {2012},
  journal = {PloS one},
  volume = {7},
  pages = {e47498},
  month = {2012},
  issn = {1932-6203},
  url = {http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0047498},
  doi = {10.1371/journal.pone.0047498},
  language = {eng},
}