@article{24360,
  keywords = {Adult, Brazil, Disease resistance, Female, Haplotypes, Humans, Interleukin-10, leprosy, Male, Middle Aged, Polymorphism, Single Nucleotide},
  author = {Garcia P and Alencar D and Pinto P and Santos N and Salgado CG and Sortica VA and Hutz M and Ribeiro-Dos-Santos A and Santos S},
  title = {Haplotypes of the IL10 gene as potential protection factors in leprosy patients.},
  abstract = {<p>Leprosy is an infectious disease caused by Mycobacterium leprae characterized by dermatoneurological signs and symptoms that has a large number of new cases worldwide. Several studies have associated interleukin 10 with susceptibility/resistance to several diseases. We investigated haplotypes formed by three single nucleotide polymorphisms (SNPs) located in the IL10 gene (A-1082G, C-819T, and C-592A) in order to better understand the susceptibility to and severity of leprosy in an admixed northern Brazil population, taking into account estimates of interethnic admixture. We observed the genotypes ACC/ACC (P = 0.021, odds ratio [OR] [95% confidence interval (CI)] = 0.290 [0.085 to 0823]) and ACC/GCC (P = 0.003, OR [95% CI] = 0.220 [0.504 to 0.040]) presenting significant results for protection against leprosy development, framed in the profiles of low and medium interleukin production, respectively. Therefore, we suggest that genotypes A-1082G, C-819T, and C-592A formed by interleukin-10 polymorphisms are closely related to protection of the leprosy development in an admixed northern Brazil population, in particular ACC/ACC and ACC/GCC genotypes. </p>},
  year = {2013},
  journal = {Clinical and vaccine immunology : CVI},
  volume = {20},
  pages = {1599-603},
  month = {2013 Oct},
  issn = {1556-679X},
  url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3807203/pdf/zcd1599.pdf},
  doi = {10.1128/CVI.00334-13},
  language = {eng},
}