@article{2437,
  keywords = {Animals, Anti-Infective Agents, Antitubercular Agents, Clarithromycin, Clofazimine, Colony Count, Microbial, Dapsone, Drug Resistance, Microbial, Drug Resistance, Multiple, Fluoroquinolones, Humans, Leprostatic Agents, leprosy, Male, Mice, Mice, Inbred BALB C, Mice, Nude, Middle Aged, Mycobacterium leprae, Ofloxacin, Rifampin},
  author = {Matsuoka M and Kashiwabara Y and Namisato M},
  title = {A Mycobacterium leprae isolate resistant to dapsone, rifampin, ofloxacin and sparfloxacin.},
  abstract = {<p>Mycobacterium leprae were isolated from a Japanese patient, and susceptibility to antileprosy drugs was examined by the mouse foot pad method. The isolate was susceptible to clofazimine and clarithromycin, and resistant to dapsone, rifampin, ofloxacin and sparfloxacin. Mutations were identified in the genes associated with resistance to these drugs. The risk of the emergence of leprosy with multidrug resistance is emphasized.</p>},
  year = {2000},
  journal = {International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association},
  volume = {68},
  pages = {452-5},
  month = {2000 Dec},
  issn = {0148-916X},
  url = {http://ila.ilsl.br/pdfs/v68n4a07.pdf},
  language = {eng},
}