@article{24745,
  keywords = {SNPs, Rifampicin-resistant, Molecular Epidemiology, leprosy},
  author = {Singh P and Benjak A and Carat S and Kai M and Busso P and Avanzi C and Paniz-Mondolfi A and Peter C and Harshman K and Rougemont J and Matsuoka M and Cole S},
  title = {Genome-wide re-sequencing of multi-drug resistant Mycobacterium leprae Airaku-3.},
  abstract = {<p>Genotyping and molecular characterization of drug resistance mechanisms in Mycobacterium leprae enables disease transmission and drug resistance trends to be monitored. In the present study, we performed genome-wide analysis of Airaku-3, a multidrug resistant strain with an unknown mechanism of resistance to rifampicin. We identified 12 unique non-synonymous single-nucleotide polymorphisms (SNPs) including two in the transporter-encoding ctpC and ctpI genes. In addition, two SNPs were found that improve the resolution of SNP-based genotyping, particularly for Venezuelan and South-East Asian strains of M. leprae. This article is protected by copyright. All rights reserved.</p>
},
  year = {2014},
  journal = {Clinical microbiology and infection},
  month = {2014 Feb 25},
  issn = {1469-0691},
  url = {http://www.clinicalmicrobiologyandinfection.com/article/S1198-743X(14)65395-7/pdf},
  doi = {10.1111/1469-0691.12609},
  language = {eng},
}