@article{30946, keywords = {Toxin, Neglected tropical diseases (NTDs), Mycolactone A/B, Exotoxin, Buruli ulcer}, author = {Saint-Auret S and Chany A and Casarotto V and Tresse C and Parmentier L and Abdelkafi H and Blanchard N}, title = {Total syntheses of mycolactone A/B and its analogues for the exploration of the biology of Buruli ulcer.}, abstract = {

Buruli ulcer, classified as a neglected tropical disease by the World Health Organization, is caused by a mycobacterium which secretes a macrolidic exotoxin called mycolactone A/B. In this article, several synthetic strategies for the preparation of this toxin are discussed, highlighting the importance of total synthesis for the exploration of biological mechanism underpinning relevant human diseases.

}, year = {2017}, journal = {Chimia}, volume = {71}, pages = {836-840}, issn = {0009-4293}, doi = {10.2533/chimia.2017.836}, language = {eng}, }