@article{32407,
  keywords = {leprosy, CD4+ RORg-T Th17, CD25+ FOXP3+ Treg, IL17, TGF-β, Reversal reaction, Erythema nodosum leprosum (ENL)},
  author = {Yuniati R and Riawan W and Widasmara D and Darmaputra I and Arifin S},
  title = {Distribution of CD4+RORg-T Th17 and CD25+ FOXP3+ Treg in leprosy patients with reversal reaction.},
  abstract = {<p><strong><em>Objective </em></strong>To compare the distribution of CD4+ Th17 and CD25+ FOXP3 T regulatory cell (Treg) between type I reversal reaction (RR) and type II reversal reaction i.e. erythema nodosum leprosum (ENL) patient groups.</p>

<p><em><strong>Methods </strong></em>A total of 50 samples, consisted of 27 samples of reversal reaction (RR) and 23 samples of ENL, were collected. Observation of CD4+ RORg-T Th17 and CD25+ FOXP3 Treg were conducted with immunohistochemistry staining technique using anti FOX-P3 and anti RORg-T. Expression of CD4+ ROR-g Th17 and CD25+ FOXP3 Treg in percentage were analyzed using T-test.</p>

<p><em><strong>Results </strong></em>There is a significant difference in mean CD4+ ROR-g Th17 and IL17 cell distribution for RR patient group (14.96% and 10.72%) compared with ENL (9.12% and 4.28%). No significant difference were found between mean CD25+ FOXP3 Treg and TGF-β cell distribution in RR patient group (6.12% and 5.44%) compared with ENL group (6.16% and 5.96%).</p>

<p><em><strong>Conclusion </strong></em>There is a significant increment od CD+RORg-T Th17 and IL17 in RR patients group compared with ENL patients group. however, the distribution of CD25+ FOXP3+ Treg and TGF beta in RR has no significant difference compared with ENL.</p>
},
  year = {2018},
  journal = {Journal of Pakistan Association of Dermatologists : JPAD},
  volume = {28},
  pages = {123-128},
  url = {http://jpad.com.pk/index.php/jpad/article/viewFile/1102/1099},
  language = {eng},
}