@article{32969,
  keywords = {leprosy, Histomorphology, Borderline tuberculoid, Lepromatous, Granuloma, Skin biopsy, India, Navi Mumbai, Histopathology},
  author = {Roy P and Dhar R and Patro P and M B H and Sahu S},
  title = {Histopathological Study of Leprosy Patients in a Tertiary Care Hospital in Navi Mumbai},
  abstract = {<p><strong>Background: </strong>Leprosy or Hansen’s disease is a chronic infectious disease that mainly affects skin and peripheral nerves. Histopathology and demonstration of lepra bacilli is a vital tool to supplement clinical examination and diagnosis for correct classification and therefore treatment of patients. <strong>Aim: </strong>To study histopathology of leprosy cases and identify histological types in patients in a tertiary care hospital in Navi Mumbai. <strong>Materials and Methods</strong>: 50 skin biopsies diagnosed as leprosy over a period of two years from January 2017 to December 2018 were studied. Haematoxylin-eosin and Fite-Faraco staining for demonstrating lepra bacilli were done. <strong>Results: </strong>Male to female ratio of patients was 4.5:1. Maximum number of cases was seen in the 3rd decade of life. The commonest histological type was borderline tuberculoid (18 cases, 36%), followed by tuberculoid type (8 cases, 16%); least common cases were of borderline lepromatous, indeterminate and histoid types (4 cases, 8%). The most common site was forearm (26%). All 12/50(24%) patients with affected nerves showed ulnar nerve involvement. Hypopigmented, anaesthetic plaque was the commonest clinical feature followed by erythematous lesions. All cases of histoid and lepromatous type showed acid-fast bacilli on Fite stain. Tuberculoid cases showed perineural infiltration and well-formed granulomas, borderline tuberculoid type showed additional feature of giant cells and lepromatous types showed grenz zone and no granulomas. Histoid type showed fusiform histiocytes resembling spindle cells. <strong>Conclusion: </strong>Histopathological examination is the gold standard for accurate diagnosis and typing of leprosy. It should be done in all leprosy cases presenting to the clinician.</p>
},
  year = {2019},
  journal = {International journal of health sciences & research},
  volume = {9},
  pages = {6-12},
  url = {http://www.ijhsr.org/IJHSR_Vol.9_Issue.2_Feb2019/2.pdf},
  language = {eng},
}