@article{33631, author = {Saha R and Sarkar S and Majumder M and Banerjee G}, title = {Bacteriological profile of aerobic and anaerobic isolates of trophic ulcer in leprosy: A study from Eastern India.}, abstract = {

Introduction: Trophic ulcer is a dreaded complication of leprosy. Secondary infection compounds the damage to the already neglected ulcer.

Aims: To find out the bacterial pathogens in the isolates from trophic ulcers of leprosy and to find the drug sensitivity of the aerobic isolates so as to start a suitable antibiotic therapy.

Methodology: An institution-based, cross-sectional study done over a period of 2 years. Swab was taken from the deeper part of the ulcer. It was put on a suitable culture media. Bacteriological profile was determined and antibiogram was done subsequently.

Results: Sixty patients with trophic ulcer secondary to leprosy were screened, among which all were screened for aerobic isolates and 38 were screened for anaerobic isolates. Among the aerobic isolates, 88% of patients were culture-positive. The most common organism was (37.7%), followed by (22.64%), (15.09%), (13.2%), (9.43%). Maximum overall sensitivity was seen with amikacin (93.1%) and linezolid (89.65%). Maximum overall resistance was noted with cotrimoxazole (58.62%) and coamoxiclav (51.72%). Among the 38 patients cultured for anaerobic isolates, 17 were culture-positive for anaerobic organisms. Isolates showing were 6 (15.7%), purely were 4 (10.5%), purely bacteroides were 3 (7.8%), and mixed growths were 4 (10.5%).

Conclusion: Secondary bacterial infection is quite common in leprosy trophic ulcers. The most common organism was . Isolates were mostly sensitive to amikacin and linezolid and resistant to cotrimoxazole and coamoxiclav. Anaerobic isolates were not uncommon, with being the most common among them.

}, year = {2019}, journal = {Indian journal of dermatology}, volume = {64}, pages = {372-376}, issn = {1998-3611}, doi = {10.4103/ijd.IJD_310_19}, language = {eng}, }