@article{95053,
  author = {Dubey A and Gaur R and Arela N and Singh V and Arora M and Sagar H and Kamal R and Natarajan M and Bhagyawant SS and Patil SA and Mohanty KK},
  title = {Soluble mediators of immune significance in sera of leprosy patients},
  abstract = {Background:<br>
The disease leprosy is categorized by a wide spectrum of clinical forms imposed by the patient’s immune responses to the organism, Mycobacterium leprae. Soluble receptors and soluble mediators are important for regulation of immune responses.
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Objectives:<br>
As leprosy reactions are known immune inflammatory reactions during the disease process, the aim of the study was to screen nitrite, IL-6 cytokine and sTLR2 in sera samples to identify circulating biomarkers associated with leprosy and T1R and T2R among patients recruited from the Northern part of India.
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Methods:<br>
Leprosy patients recruited in our Institute were included in this study. We analysed the level of nitrite, soluble TLR2 and IL-6 in sera of leprosy patients, healthy controls and healthy household contacts by colorimetric assay and ELISA respectively.
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Results:<br>
The level of serum nitrite was observed to be higher in tuberculoid leprosy patients compared to lepromatous leprosy patients (p = 0.006). The level was also higher in healthy contacts of leprosy patients compared to lepromatous leprosy patients (p = 0.008). The sTLR2 level was significantly higher in healthy controls than leprosy patients (p = 0.002) and their healthy contacts (p = 0.001). The level of IL-6 in serum was significantly higher in leprosy patients than in healthy controls (p = 0.001).
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Conclusion:<br>
Nitrite, IL-6 cytokine and sTLR2 are shown to be potential circulating biomarkers associated with leprosy among patients recruited in Northern India.},
  year = {2020},
  journal = {Leprosy Review},
  volume = {91},
  pages = {403-412},
  publisher = {Lepra},
  issn = {2162-8807},
  url = {https://leprosyreview.org/admin/public/article_shell/uploads/article_files/Lepra/LEPROSY/91/4/lr2020021/lr2020021.pdf},
  doi = {10.47276/lr.91.4.403},
  language = {eng},
}