@article{95659,
  keywords = {Cytokine, gene polymorphism, interferon gamma, interleukin, leprosy, tumor necrosis factor alpha},
  author = {Kolla V and Sultana S and Davala S and Valluri V},
  title = {A Study on the Impact of Genetic Polymorphisms of Cytokines TNFα, IFNγ and IL10 in South Indian Leprosy Patients.},
  abstract = {<p><b>Background: </b>Leprosy (Hansen's disease) is a chronic, debilitating disease predominantly of the peripheral nervous system characterized by the impairment of peripheral nerves and subsequent sensory loss caused by . The pro- and antiinflammatory cytokine genes play a major role in nerve damage in leprosy.</p><p><b>Aims and Objectives: </b>The objective of the present study is to ascertain the association of cytokine gene polymorphisms TNFα - 308G/A (rs 1800629), IFNγ +874A/T (rs 2430561), and IL10 - 1082G/A rs 1800896 in causation with leprosy.</p><p><b>Materials and Methods: </b>The present study comprised 365 leprosy patients and 185 control subjects. The polymorphisms in TNFα-308, IFNγ+874, and IL10-1082 genes were typed using the amplification refractory mutation system polymerase chain reaction method (ARMS PCR).</p><p><b>Results: </b>The present study found significant association between IL10-1082 GA heterozygote ( < 0.02) and IFNγ+874 AA ( < 0.001) genotype and leprosy. TNFα-308GA could not establish any association with the disease.</p><p><b>Conclusion: </b>The identification of genetic variations in pro- and antiinflammatory cytokines that are susceptible to leprosy would assist in better understanding of the pathogenesis of leprosy and perhaps lead to new approaches for diagnosis and treatment.</p>},
  year = {2021},
  journal = {Indian journal of dermatology},
  volume = {66},
  pages = {138-144},
  month = {01/2021},
  issn = {1998-3611},
  url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8208288/},
  doi = {10.4103/ijd.IJD_684_20},
  language = {eng},
}