@article{96012, keywords = {Cell mediated immunity, epidermodysplasia, leprosy}, author = {Tripathy D and Neema S and Kinra P and Sinha P}, title = {Lepromatous leprosy in a case of epidermodysplasia verruciformis - A coincidence or a result of defective cell-mediated immunity?}, abstract = {
Epidermodysplasia verruciformis (EDV) is a rare, autosomal recessive, genetic disorder of immune dysregulation characterized by increased susceptibility to cutaneous human papilloma virus infections. It was first described by Lewandowsky and Lutz in 1922 as a form of epidermal nevus. Its association with skin cancers was proposed by Sullivan and Ellis in 1939. Initial lesions often occur in childhood and are of two types; lifelong eruptions of pityriasis versicolor like lesions and flat wart like papules. The latter is characterized by malignant transformation in 35%-50% of patients especially after 40-50 years of age. Bowen disease is the most common tumor followed by invasive squamous cell carcinoma, however, metastasis is rarely encountered.
}, year = {2021}, journal = {International journal of mycobacteriology}, volume = {10}, pages = {210-213}, month = {01/2021}, issn = {2212-554X}, url = {https://www.ijmyco.org/temp/IntJMycobacteriol102210-3371611_092156.pdf}, doi = {10.4103/ijmy.ijmy_19_21}, language = {eng}, }