@article{97617,
  keywords = {IL-17A, IL-23, ROR, Dermis, gamm delta T cell, leprosy},
  author = {Liu Y and Shi C and Ma S and Ma Y and Lu X and Zhu J and Yang D},
  title = {The protective role of tissue-resident interleukin 17A-producing gamma delta T cells in Mycobacterium leprae infection.},
  abstract = {<p>Mycobacterium is a kind of disease-causing bacteria and results in leprosy in human. Gamma delta (γδ) T cell is a T-cell subset that is presented in both human dermis and epidermis. These cells bridge innate and adaptive immune responses and play critical roles in regulating anti-microbial defense, wound healing, and skin inflammation. Here, we investigated skin resident γδ T cells in patients with leprosy. Our data showed that γδ T cells significantly accumulated in skin lesions of leprosy patients with tuberculoid (TT) form. IL-23 can predominantly stimulate dermal γδ T cells to produce interleukin 17 (IL-17), a cytokine which may lead to disease protection. These γδ T cells expressed a specific set of surface molecules, and majority of these cells were Vδ1. Also, IL-23 can stimulate the expansion of dermal γδ T cells expansion. Moreover, our results revealed that the transcription factor RORγt was responsible for IL-17A expression in leprosy lesion. Therefore, these data indicated that IL-23-responsive dermal γδ T cells were the major resource of IL-17A production in the skin and could be a potential target in the treatment of leprosy.</p>
},
  year = {2022},
  journal = {Frontiers in immunology},
  volume = {13},
  pages = {961405},
  month = {01/2022},
  issn = {1664-3224},
  url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9644052/pdf/fimmu-13-961405.pdf},
  doi = {10.3389/fimmu.2022.961405},
  language = {eng},
}