@article{97693,
  keywords = {General Energy},
  author = {Muthusamy S and Vilvanathan SA and Dhandapany SP and Bhagat VM and Chadha VK and Sivashanmugam E and Kamalanathan A and Lakshmanan S and Mani M},
  title = {Molecular detection of drug resistance in clinical specimens of leprosy patients from a tertiary care leprosy centre in South India},
  abstract = {<p>Background</p>

<p>Leprosy is one of the neglected tropical diseases (NTD) experiencing relative stagnancy in the global number of new cases.</p>

<p>Objective</p>

<p>This study aims to find the proportion of antimicrobial resistance in the clinical specimens of leprosy patients attending a tertiary care leprosy Institute in South India.</p>

<p>Materials and methods</p>

<p>Skin biopsy specimens (31&nbsp;Nos) were tested by Polymerase chain reaction (PCR) for identification of&nbsp;M.&nbsp;leprae, and PCR followed by DNA sequencing for antimicrobial resistance (AMR) detection.</p>

<p>Results</p>

<p>All 31 specimens tested for&nbsp;M.&nbsp;leprae&nbsp;identification were positive. Resistance to dapsone was 6.5%, while rifampicin and ofloxacin showed 100% sensitivity.</p>

<p>Conclusion</p>

<p>This study warrants the need for a vigilant surveillance mechanism to monitor the trend of antimicrobial resistance in leprosy.&nbsp;</p>
},
  year = {2022},
  journal = {Leprosy Review},
  volume = {93},
  pages = {370-376},
  publisher = {Lepra},
  issn = {2162-8807},
  url = {https://leprosyreview.org/admin/public/api/lepra/website/getDownload/63945627afaac14a3c48a28b},
  doi = {10.47276/lr.93.4.370},
  language = {Eng},
}