@article{98236,
  keywords = {Acute renal failure, adverse drug reaction, leprosy, Rifampicin},
  author = {Jeyasekharan R and George N},
  title = {Rifampicin Allergy Leading to Acute Renal Shutdown.},
  abstract = {<p>Rifampicin is a widely used drug to treat tuberculosis and leprosy. Its toxicity is predominantly hepatic and immunoallergic in character. While hepatic toxicity is dose-related, the immunoallergic effects are unpredictable and usually associated with intermittent therapy. These immunoallergic effects may be minor (a cutaneous, gastrointestinal, or influenza-like syndrome) or major (hemolytic anemia, shock, or acute renal failure). Herein, we report a case of rifampicin allergy in a patient who was on intermittent once monthly rifampicin therapy for neuritic leprosy and was on his 4 month of treatment. Rifampicin exposure led to sudden shock and acute renal failure, which eventually required hemodialysis support. The patient made a complete recovery over the subsequent days and his renal function returned to normal over the next 3 weeks. He continues his multidrug therapy of leprosy without rifampicin.</p>
},
  year = {2023},
  journal = {International journal of applied & basic medical research},
  volume = {13},
  pages = {47-49},
  month = {01/2023},
  issn = {2229-516X},
  url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10230526/pdf/IJABMR-13-47.pdf},
  doi = {10.4103/ijabmr.ijabmr_198_22},
  language = {eng},
}