@article{98516,
  keywords = {immune markers, inflammatory cytokine, leprosy, Leprosy complications, soluble TREM-1},
  author = {Bezerra-Santos M and Bomfim L and Santos C and Cunha M and de Moraes E and Cazzaniga R and Tenório M and Araujo J and Menezes-Silva L and Magalhães L and Barreto A and Reed S and Duthie M and Lipscomb M and de Almeida R and de Moura T and de Jesus A},
  title = {sTREM-1 and TNF-α levels are associated with the clinical outcome of leprosy patients.},
  abstract = {<p>Leprosy reaction (LR) and physical disability (PD) are the most significant clinical complications of leprosy. Herein, we assessed the circulating serum-sTREM-1 and TNF-α levels and their genetic polymorphisms in leprosy. Serum-sTREM-1 and TNF-α levels were measured in leprosy patients (LP) before treatment ( = 51) and from their household contacts (HHCs; = 25). DNA samples were genotyped using TREM-1 rs2234246 and TNF-α rs1800629-SNP in 210 LPs and 168 endemic controls. The circulating sTREM-1 and TNF-α levels are higher in the multibacillary form. The ROC curve of the serum-sTREM-1 levels was able to differentiate LR from non-LR and PD from non-PD. Similarly, LPs with serum-sTREM-1 levels &gt;210 pg/ml have 3-fold and 6-fold higher chances of presenting with LR and PD, respectively. Genotypes CC+CT of the TREM-1 were associated with leprosy. Taken together, our analyses indicated that sTREM-1 and TNF-α play an important role in the pathogenesis of leprosy and provide promising biomarkers to assist in the diagnosis of leprosy complications.</p>
},
  year = {2023},
  journal = {Frontiers in medicine},
  volume = {10},
  pages = {1-8},
  month = {01/2023},
  issn = {2296-858X},
  url = {https://www.frontiersin.org/articles/10.3389/fmed.2023.1177375/pdf},
  doi = {10.3389/fmed.2023.1177375},
  language = {eng},
}