@article{99070,
  keywords = {Immune Response, Interleukin-17},
  author = {Zaniolo L and Damazo A},
  title = {Th17 Cells and Cytokines in Leprosy: Understanding the Immune Response and Polarization.},
  abstract = {<p>While there are conflicting data concerning interleukin (IL)-17 levels in the serum of patients with leprosy compared with those in healthy controls, higher levels have been more evident in the tuberculoid clinical form of leprosy and type 1 reactions. This review aimed to highlight the role of Th17 cells and their cytokines in leprosy. Cytokines such as IL-1β and IL-23 induce Th17, while transforming growth factor beta and IL-10 inhibit Th17, indicating that the balance between Th17 and regulatory T cells is crucial for leprosy polarization. However, more comprehensive paired studies are required to better elucidate the role of Th17 cells in leprosy.</p>
},
  year = {2023},
  journal = {Revista da Sociedade Brasileira de Medicina Tropical},
  volume = {56},
  pages = {1-5},
  month = {01/2023},
  issn = {1678-9849},
  url = {https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10615336/pdf/1678-9849-rsbmt-56-e0265-2023.pdf},
  doi = {10.1590/0037-8682-0265-2023},
  language = {eng},
}