@article{99336,
  keywords = {Household contacts, IgM antiphenolic glycolipid-1 antibody, leprosy, single-dose rifampicin},
  author = {Fantoni O and Rusmawardiana R and Yahya Y and Bahar E and Toruan T and Purwoko M},
  title = {Comparison of antiphenolic glycolipid-1 antibody levels in seropositive contacts of leprosy after 2 years of single-dose rifampicin as postexposure prophylaxis.},
  abstract = {<p><strong>Background: </strong>Leprosy is still a global problem, especially in developing countries, including Indonesia. Ineffective prevention of leprosy leads to active transmission of the disease. World Health Organization (WHO) recommend post-exposure prophylaxis (PEP) with single dose of rifampicin (SDR) for leprosy patients. Previous study showed protective effect of SDR against leprosy, especially for the first 2 years. Hence, the use of PEP and IgM anti PGL-1 examination are required to suspend the chain of leprosy transmission. This study evaluated the effectiveness of SDR administration by comparing IgM anti-PGL-1 antibody levels in seropositive household contacts before and after 2 years of SDR administration.</p>

<p><strong>Methods: </strong>Analytical observational laboratory study comparing IgM anti PGL-1 antibody levels before and after 2 years of SDR administration in leprosy contacts, with a prospective follow-up study design. We conducted this study from December 2022 to January 2023 at Dr. Mohammad Hoesin General Hospital Palembang. All seropositive household contacts of leprosy who had been administrated SDR 2 years ago were included, then PGL-1 antibody levels were examined.</p>

<p><strong>Results: </strong>The use of SDR showed significant improvement in leprosy contacts after 2 years (P=0.000). The median antibody level before SDR administration was 1,209.20 (615.81 - 4,353.60), which decrease to 146.03 (0 - 2,487.80) U/mL after 2 years. There was statistically significant relationship between history of BCG vaccination (P=0.003) and IgM PGL-1 antibody levels after 2 years of SDR administration.</p>

<p><strong>Conclusion: </strong>There is a significant decrease in IgM anti PGL-1 antibody levels among leprosy contacts after 2 years of SDR chemoprophylaxis administration.</p>
},
  year = {2023},
  journal = {International journal of mycobacteriology},
  volume = {12},
  pages = {399-406},
  month = {01/2023},
  issn = {2212-554X},
  doi = {10.4103/ijmy.ijmy_118_23},
  language = {eng},
}