01544nas a2200217   4500000000100000008004100001260001200042653001500054653002100069653002100090653001500111653002900126100001900155700001000174700002200184700002100206245010500227856010400332520087600436022001401312       2024                            d  c05/202410aDisability10aHansen's disease10aHypersensitivity10aImmunology10aMycobacterium Infections1 aSerrano-Coll H1 aWan E1 aRestrepo-Rivera L1 aCardona-Castro N00aLeprosy Reactions: Unraveling Immunological Mechanisms Underlying Tissue Damage in Leprosy Patients.  uhttps://academic.oup.com/femspd/advance-article-pdf/doi/10.1093/femspd/ftae013/57955578/ftae013.pdf3 a<p>Leprosy is a chronic granulomatous infectious and disabling disease caused by two mycobacteria, Mycobacterium leprae and Mycobacterium lepromatosis. Acute inflammatory responses, known as leprosy reactions, are significant contributors to disabilities. Three types of leprosy reactions have been identified based on excessive cytokine release (e.g. type 1) or the accumulation of immune complexes in tissues inducing multiorgan damage (e.g. types 2 and 3). The type of leprosy reaction has implications on treatment and management strategies, yet are not well understood by health workers caring for leprosy patients. We attempt to describe the immunologic mechanisms behind the different leprosy reactions and the rationale for tailoring clinical treatment and management to the particular type of leprosy reaction based on the underlying immunologic situation.</p>
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