01949nas a2200205   4500000000100000008004100001653001800042653001200060653002200072653000900094100002000103700002300123700001400146700001700160700001400177245011400191856007800305300000800383520135200391       2024                            d10aCurcuma longa10aLeprosy10aReversal reaction10aIL-61 aNurisma Putri S1 aPutra Mundhofir FE1 aYuniati R1 aWijayahadi N1 aNindita Y00aEffect of Curcuma longa Extract as Adjuvant Therapy on IL-6 Serum Levels in Leprosy  Type 1 Reaction Patients  uhttps://jurnal.healthsains.co.id/index.php/jhs/article/download/1301/1380  a1-93 a<p>Type 1 leprosy reaction / Reversal reaction (RR) is an inflammatory episode in existing leprosy lesions and aggravates the pain rate. Long-term therapy with steroids causes a variety of side effects, so an adjuvant therapy alternative is needed to alleviate steroid use. Curcuma longa rhizome extract has become an anti-inflammatory therapy choice in various previous inflammatory diseases. This study aims to determine the antiinflammatory effect of Curcuma longa rhizome extract as an adjuvant therapy for reversal reaction patients by analyzing serum levels of IL-6 as a marker of inflammation. The pre and post-test randomized single-blinded controlled trial was conducted on two groups, namely control (RR patients with steroid therapy &amp; placebo) and treatment (steroid therapy &amp; Curcuma longa rhizome extract 1 gram/day). IL-6 serum levels were analyzed from sampling before and after the intervention for one month. The serum levels of IL-6 post-test in the control group were significantly higher than those of the pre-test. The treatment group showed lower serum levels of IL-6 post-test compared to pre-test, although there was no significant difference. Curcuma longa rhizome extract 1 gram/day for one month as adjuvant therapy for patients with type 1 leprosy reaction did not significantly reduce serum IL-6 levels.</p>