02064nas a2200205   4500000000100000008004100001653001800042653001800060653003300078653003400111100001500145700001400160700002300174700001700197700001500214245015600229856008000385300000800465520138500473       2024                            d10aleprosy ulcer10aWound Healing10aPressure Ulcer Score Healing10aTransforming Growth Factor-β1 aAlfarizi R1 aYuniati R1 aPutra Mundhofir FE1 aWijayahadi N1 aNindita  Y00aCorrelation between TGF-β Levels and Degree of Wound Healing in Leprosy Ulcer Patients: An Observational Study at dr. Rehatta Regional Hospital Jepara  uhttps://ejournal3.undip.ac.id/index.php/medico/article/download/44999/31487  a1-43 a<p><strong>Background:&nbsp;</strong>Ulcers are one form of chronic wounds as one form of complication experienced by leprosy sufferers. In the process of healing wounds such as ulcers, TGF-β has a broad role. Several studies have stated that in chronic wound conditions there is a decrease in TGF-β levels so that the wound is increasingly difficult to heal. This study aims to determine the relationship between TGF-β serum levels and the degree of ulcer wound healing.&nbsp;</p>

<p><strong>Methods:&nbsp;</strong>This study is an observational analysis study with a cross-sectional design and involved 33 leprosy ulcer patients undergoing treatment at the dr. Rehatta Jepara Hospital in the period March-April 2024. Serum TGF-β levels were measured using the Enzyme-linked immunosorbent assay (ELISA) method while the degree of wound healing was assessed by scoring the Pressure Ulcer Scale for Healing (PUSH). Bivariate analysis using the Spearman Correlation Rank Test.&nbsp;</p>

<p><strong>Results:</strong>&nbsp;The correlation test between serum TGF-β levels and the degree of wound healing (p = 0.807) and duration of leprosy as covariate (p = 0.96) showed insignificant results.<em>&nbsp;</em></p>

<p><strong>Conclusion:&nbsp;</strong>There is no relationship between serum TGF-β levels and the degree of wound healing and duration of leprosy.&nbsp;</p>