01522nas a2200157   4500000000100000008004100001653001200042653001200054653001200066653001200078100001500090245007000105856008800175300000800263520109300271       2024                            d10aDe novo10ahistoid10aDapsone10aLeprosy1 aSiddiqui M00aDe-novo Histoid Leprosy: A Case Report and a Review of Literature  uhttps://www.ijl.org.in/published-articles/26062024082041/7_Case_Report_Siddique.pdf  a1-83 a<p>Histoid leprosy is a rare type of multibacillary leprosy and an uncommon variant of lepromatous leprosy. It typically manifests as relapse in lepromatous individuals on dapsone monotherapy, but de novo occurrences are rare. Even skilled dermatologists may struggle to make a diagnosis for this uncommon type of disease. Histoid leprosy has distinctive clinical and histopathological characteristics. We describe a case in a young male with small to big papular lesions all over his body appeared as a de novo occurrence. These lesions ranged in size from 0.5 cm to 2 cm and were flesh-colored, shiny, almost symmetrical, and soft to firm in consistency. The scalp, ears, oral cavity, nose, palms, soles, and genitalia were spared. There was no lymph node enlargement or nerve thickening. Pain, touch, or temperature sensations were unaffected. There was no visible deformity. Slit-skin smears from normal skin were negative. This case was confirmed as histoid leprosy based on characteristic histopathological features and positivity for acid fast bacilli (AFB) from the lesions.</p>