03069nas a2200253   4500000000100000008004100001260001200042653002900054653001200083653001200095653001500107653003200122100001200154700002000166700001600186700001200202700001400214245015700228856011000385300001200495490000700507520227600514022002502790       2024                            d  bMedknow10amulti-drug therapy (MDT)10aLeprosy10aDapsone10ahaemolysis10atherapeutic decision making1 aBhatt S1 aRadhakrishnan S1 aVasudevan B1 aNeema S1 aKothari R00aStudy of Haemolysis in Patients of Leprosy Being Administered Multi-Drug Therapy at a Tertiary Care Hospital in Western Maharashtra: A Prospective Study  uhttps://journals.lww.com/ijd/fulltext/2024/05000/study_of_haemolysis_in_patients_of_leprosy_being.18.aspx  a282-2820 v693 a<p><strong>Introduction: </strong>Dapsone forms the backbone of multi-drug therapy (MDT) in leprosy and many other dermatological disorders. Haemolysis is its common side effect which often necessitates drug stoppage. Currently, wide variation in data of haemolysis with dapsone exists in literature ranging from 24.7% to 83% and none of the studies point towards the timing of onset of haemolysis/timing of maximal haemolysis which is important in therapeutic decision making regarding continuing or stopping the drug. This study aimed to answer such unanswered questions.</p>

<p><strong>Objectives: </strong>Primary: To estimate the fall in haemoglobin (Hb) levels after administering MDT for 3 months in patients with leprosy. Secondary: To determine factors associated with Hb change – age, glucose-6-phosphate dehydrogenase (G6PD) status, pole of leprosy and duration of MDT taken (if any).</p>

<p><strong>Materials and Methods: </strong>All freshly diagnosed cases of Hansen’s disease were studied for 3 months. At baseline, demographic data (age, sex), skin biopsy, slit skin smear and G6PD were taken. Haemoglobin (Hb), serum glutamate oxaloacetate transferase (SGOT), serum glutamate pyruvate transferase (SGPT), serum bilirubin, lactate dehydrogenase (LDH), reticulocyte count, peripheral blood smear (PBS) along with clinical photography was done at baseline, 1, 2 and 3 months.</p>

<p><strong>Results: </strong>Out of the 48 patients who completed the study: Mean Hb (g/dL) decreased from 13.37 at baseline to a minimum of 12.08 at 2 months, and then increased to 12.34 at 3 months. Of 42 patients (87.5%) with a fall in Hb, 13 (27.1%) had severe (fall &gt;20%), 17 (35.4%) had moderate (fall 10–20%), 12 (25%) had mild fall (fall &lt;10%) and in 6 (12.5%), there was no haemolysis. Reticulocyte count, LDH, SGOT and SGPT were significantly associated with haemolysis. Severe haemolysis occurred more frequently in the lepromatous spectrum.</p>

<p><strong>Conclusion: </strong>Dapsone causes maximal fall of hemoglobin by 1.29 g/dl at two months following which it increases. The fall of hemoglobin is reversible and hemoglobin starts to increase by 3 months of therapy making cessation of the drug unnecessary in most of the patients.</p>
  a0019-5154, 1998-3611