01799nas a2200181   4500000000100000008004100001653003600042653002900078653001200107100001300119700001100132700001300143700001200156245015200168856007500320300000800395520121400403       2024                            d10aErythema nodosum leprosum (ENL)10aVitamin D Receptor (VDR)10aLeprosy1 aAznamry 1 aAmin S1 aDjawad K1 aIlyas F00aAnalysis  of  vitamin  D  receptor  levels  in  serum  of leprosy   patientsof multibacillary   type,   erythema nodosum leprosum and normal people  uhttps://www.jpad.com.pk/index.php/jpad/article/download/2592/2335/9547  a1-53 a<p>&nbsp;</p>

<p><strong>Objective: </strong>Erythema Nodosum Leprosum(ENL) is an acute inflammatory reaction that occurs only in multibacillary (MB) leprosy patients. Serum Vitamin D Receptor (VDR) has been widely used as a biomarker to determine the progress of therapy in various diseases. This study aims to determine thedifference between serum VDR in MB type leprosy patients who experience ENL reactions and those who do not experience ENL reactions and healthy people.</p>

<p><strong>Methods: </strong>The research was conducted using an analytic observational study with a cross sectional method. The total number of samples is 36 people, where each group consists of 12 people.</p>

<p><strong>Results:</strong> Mean serum VDR of multibacillary leprosy patients with an ENL reaction was 10.41 (4.34±18.12), whereas in the group without ENL it was 25.92 (23.32±29.42) and in the healthy group it was 39.51 (34.54±42.67).</p>

<p><strong>Conclusion:</strong> Based on statistical tests, it was found that serum VDR was significantly different between multibacillary leprosy patients who experienced ENL reactions and patients who did not experience ENL reactions and healthy people.</p>