02140nas a2200229   4500000000100000008004100001260004400042653002400086653001500110653002100125653000900146653002300155100001200178700001200190700001400202700001600216245007500232856008800307300000800395520149300403022001401896       2024                            d  bSpringer Science and Business Media LLC10amultidrug treatment10aneuropathy10ahypopigmentation10anlep10ahansen’s disease1 aAhmed S1 aPatel M1 aChakole S1 aChoudhari S00aLeprosy Presenting With Scleroderma and Cataract: A Clinical Conundrum  uhttps://assets.cureus.com/uploads/case_report/pdf/252226/20240725-319105-drv0e3.pdf  a1-93 a<p>Leprosy, a chronic infectious disease caused by Mycobacterium leprae, even though treatable, remains a significant public health problem. It mainly impacts the skin, peripheral nerves, mucosa of the upper respiratory tract, and the eyes. In this case report, we present the case of a 64-year-old female with numerous hypopigmented patches with loss of sensations, madarosis, resorption of toes and digits, skin tightening, and diminution of vision. The skin over the hands exhibited thickening, leading to functional impairments that influenced both manual dexterity and mobility. The diagnosis of this unique case, showing a complex triad of lepromatous leprosy, scleroderma, and sclerotic cataract, was confirmed by clinical evaluation, skin biopsies, serological tests, and ophthalmic examination. Following this, the patient underwent dexamethasone-cyclophosphamide pulse therapy and multidrug treatment to halt the disease progression, prevent further disability, and reduce transmission. The case management addressed the issue of overlapping symptoms and conditions to provide appropriate care and cure to the patient. Public health initiatives under the National Leprosy Eradication Programme play an important role in promoting early diagnosis, effective treatment, and community empowerment, working toward a future where leprosy is no longer a threat to public health by preventing disability, reducing transmission, and combating the social stigma associated with it.</p>
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