01344nas a2200217   4500000000100000008004100001260001200042653003600054653002000090653002000110653001400130653001200144100001400156700001400170700001400184700001400198700001200212245015200224520073600376022001401112       2024                            d  c07/202410aNerve function impairment (NFI)10aType 1 reaction10aType 2 reaction10aTreatment10aLeprosy1 aKhurana A1 aSharath S1 aPanchal A1 aSardana K1 aGupta S00aCase Report: Recurrent Type 2 Leprosy Reaction Associated with Multiple Nerve Function Impairments Refractory to Steroids: A Therapeutic Challenge.3 a<p>Nerve function impairment (NFI) in leprosy results in serious deformities of the face, hands, and feet and contributes significantly to the stigma associated with the disease. Most literature on NFI focuses on either type 1 reaction-associated NFI, or the silent neuropathy, whereas NFI associated with type 2 reaction (T2R) is less well researched. The latter, however, can be more refractory to conventional treatment, not solely owing to its recurrent nature. We present a therapeutically challenging case of a 31-year-old male with borderline lepromatous leprosy with recurrent T2R associated with recurrent and progressive sensorimotor NFI, largely unresponsive to oral steroids and multibacillary, multidrug therapy.</p>
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