01446nas a2200217   4500000000100000008004100001260002200042653002500064653001400089653001600103653001400119100001300133700001400146700001700160700001500177700001700192700001700209245008600226520089100312022002501203       2024                            d  bSAGE Publications10anovo histoid leprosy10aDiagnosis10aCase report10aTreatment1 aAnaje CC1 aOkpala CI1 aEnechukwu NA1 aMenkiti FE1 aEzejiofor IF1 aUmenzekwe CC00aA case report of de novo histoid leprosy in a Nigerian male: A diagnostic dilemma3 a<p>Histoid leprosy is an uncommon variant of lepromatous leprosy. It poses a diagnostic challenge because of its distinctive clinical and histopathological features. It presents as smooth papules and nodules that rarely ulcerate. We present the case of a 22-year-old Nigerian man with a 2-year history of multiple, dome-shaped papules and nodules on the skin with necrotic centres. General examination showed right axillary lymphadenopathy, non-pitting oedema, foot ulcer, and glove and stocking sensation loss. Despite previous misdiagnoses, histopathological examination showed dermal expansion by histiocytes arranged in a storiform pattern. Slit skin smear yielded abundant bacilli. The patient was started on WHO multidrug treatment, resulting in the improvement of his lesions. This case emphasises the importance of increased awareness of this rare presentation of leprosy.</p>
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