01462nas a2200205   4500000000100000008004100001260003400042653002100076653001200097653001300109653002000122653003900142100001200181700001300193245011000206300001200316490000700328520090700335022001401242       1994                            d  bOxford University Press (OUP)10aType 1 reactions10aLeprosy10aNeuritis10aSteroid Therapy10aHuman immunodeficiency virus (HIV)1 aBwire R1 aKawuma H00aType 1 reactions in leprosy, neuritis and steroid therapy: the impact of the human immunodeficiency virus  a315-3160 v883 a<p>The incidence of type 1 reactions and neuritis among HIV seronegative and HIV seropositive leprosy patients was investigated. HIV seropositivity was associated with an increased incidence of type 1 reactions among multibacillary (MB) patients, which were observed in 9 of 12 seropositive MB patients and in 8 of 40 HIV seronegative MB patients (<em>P</em>&nbsp;&lt; 0 · 0005). Similarly, the incidence of neuritis was significantly increased among the HIV seropositive MB patients, of whom 8 developed acute neuritis compared to 3 of the HIV seronegative patients (<em>P</em>&nbsp;&lt; 0 · 0005). There was no significant difference between the numbers of paucibacillary HIV seropositive and HIV seronegative patients who developed these complications. Both the HIV seronegative and HIV seropositive patients showed a similar response to steroid therapy for the management of acute neuritis.</p>
  a0035-9203