01644nas a2200277   4500000000100000008004100001260001200042653000800054653001600062653001200078653002200090653001600112100001200128700001300140700001300153700001500166700001200181700001400193700001100207700001100218700001200229700001300241245008400254520101400338022001401352       2024                            d  c09/202410aMDT10aBedaquiline10aleprosy10aMultidrug therapy10aRepurposing1 aKhera H1 aNarang T1 aSharma A1 aMalhotra S1 aKumar V1 aChhabra S1 aKhan A1 aSuri V1 aDogra S1 aShafiq N00aExploring the therapeutic and prophylactic potential of bedaquiline in leprosy.3 a<p>Leprosy remains a significant public health concern despite major strides in treatment and control efforts. The Global Leprosy Strategy 2021-2030 and the National Strategic Plan for Leprosy 2023-2027 majorly focus on facilitating action to reach the goal of zero leprosy. Exploration of new treatment regimens is emphasized as one of the verticals of the multipronged approach for reaching the aforementioned goals. This becomes particularly pertinent in the wake of growing evidence for resistance to the drugs currently being used in the management of leprosy. Repurposed molecules present a very good approach in this direction. The present review aims to explore the potential of bedaquiline, a drug used for multidrug-resistant tuberculosis, as a potential addition to the therapeutic armamentarium of leprosy. Through this narrative review, the authors attempt to look into the available proof of concept, clinical evidence, potential risks, and possible ways forward with bedaquiline in leprosy.</p>  a1365-4632