01662nas a2200289   4500000000100000008004100001260001200042653002400054653001000078653001200088653001500100653003100115100001100146700001200157700001000169700001200179700001200191700001100203700001100214700001100225245009500236856011200331300000800443490000700451520090000458022001401358       2024                            d  c01/202410aCerebrospinal Fluid10aFever10aleprosy10anested PCR10anext-generation sequencing1 aChen H1 aJiang Y1 aShi Y1 aZhang W1 aJiang H1 aWang Z1 aZeng R1 aWang H00aFever of unknown origin, blood and cerebrospinal fluid involvement: a leprosy case report.  uhttps://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1450490/pdf?isPublishedV2=false  a1-60 v153 a<p>Leprosy is a chronic infectious disease that mainly affects the skin and peripheral nerves, it can also invade deeper tissues and organs, including mucous membranes, lymph nodes, testes, eyes, and internal organs. Severe cases can result in deformities and disabilities. We encountered the case of a 39-year-old male with unexplained fever, headache and rash. The patient's lesions were taken for histopathological examination and slit skin smear analysis. Further, the patient was detected of  nucleic acid sequences in the cerebrospinal fluid (CSF) and plasma, and  gene targets in the skin lesion tissue and blood. The patient was eventually diagnosed with multibacillary leprosy and type II leprosy reaction. These results suggest the possibility of bacteremia in patients with leprosy to some extent, and observation implies the potential invasion of CSF by  or its genetic material.</p>  a1664-3224