01716nas a2200337   4500000000100000008004100001260001200042653001300054653002000067653001100087653001900098653001200117653001700129653001200146100001300158700001300171700001200184700001400196700001300210700001200223700001100235700001600246700001300262700001500275245007900290856009200369300000900461490000700470520088700477022001401364       2024                            d  c01/202410aCovid-1910aMycobacterium w10aCancer10aimmune therapy10aleprosy10aTuberculosis10aVaccine1 aStefan K1 aGordon R1 aRolig A1 aHonkala A1 aTailor D1 aDavis L1 aModi R1 aJoshipura M1 aKhamar B1 aMalhotra S00a Mycobacterium w - a promising immunotherapeutic intervention for diseases  uhttps://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2024.1450118/pdf  a1-200 v153 a<p>Immunomodulating agents interact with the immune system and alter the outcome of specific immune processes. As our understanding of the immune system continues to evolve, there is a growing effort to identify agents with immunomodulating applications to use therapeutically to treat various diseases. (Mw), a heat-killed mycobacterium, is an atypical mycobacterial species that possesses strong immunomodulatory properties. Mw was initially evaluated as an immune-therapeutic against leprosy, but since then Mw has generated a lot of interest and been studied for therapeutic applications across a host of diseases, such as pulmonary tuberculosis, tuberculous pericarditis, sepsis, lung cancer, and more. This article summarizes a large body of work published in the past five decades, describing various aspects of Mw and its potential for further therapeutic development.</p>
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