02349nas a2200277   4500000000100000008004100001260001200042653001100054653001200065653003500077653001700112100001800129700001600147700001200163700001400175700001600189700001500205700001000220700001400230245020000244856006700444300000800511490000600519520153200525022001402057       2024                            d  bMDPI AG10aGuinea10aleprosy10amedical-surgical complications10aCHRS Macenta1 aHébélamou J1 aGrovogui FM1 aManet H1 aPovogui L1 aBéavogui I1 aKourouma K1 aSow A1 aDelamou A00aTrend and Factors Associated with Medical–Surgical Complications in Patients Discharged from Leprosy Multidrug Therapy at the Specialized Regional Hospital in Macenta, Guinea, from 2012 to 2021  uhttps://www.mdpi.com/2414-6366/9/12/290/pdf?version=1732767470  a1-90 v93 a<jats:p>This study analyzed the trend and factors associated with medical–surgical complications in patients discharged from leprosy multidrug therapy at the Centre Hospitalier Régional Spécialisé (CHRS), in Macenta, Republic of Guinea. This was a retro 2012 (n = 54) and 2013 (n = 35) and then a slight decrease between 2014 (n = 34) and 2017 (n = 26). From 2019 (n = 18) to 2021 (n = 1), a significant d spective study using routine secondary data from 2012 to 2021. The most represented age group ranged from 25 to 59 years (73.8%), with a male predominance of 72.6%. Farmers represented 60.7% of the patients, 74.5% of the patients had plantar wounds, and 48.8% resided in the N’zerekore region. A trend analysis showed an overall significant decrease in the number of patients with complications between ecline was found. In the patients with leprosy reactions, there was a reduction in numbers from 48 in 2012 to 2 in 2014, with a predominance in men. There were significant associations between region, plantar perforation disease (p = 0.013), and physical disability (p = 0.029) and between year and leprosy reaction after the cure (p &lt; 0.001). In summary, there was a high proportion of patients with plantar ulcers, which predominantly affected farmers, and a significant proportion with leprosy reactions and physical disabilities. Community awareness around leprosy and capacity building of the providers in terms of appropriate management may contribute to improving patients’ quality of life.</jats:p>  a2414-6366