02244nas a2200265   4500000000100000008004100001260001200042653001200054653003100066653001500097653001500112100001600127700001300143700001400156700001600170700001400186700001700200700001500217245008100232856012400313300001400437490000700451520150600458022001401964       2024                            d  c11/202410aleprosy10aNeurological complications10aNeuropathy10atreatments1 aCalderone A1 aAloisi M1 aCasella C1 aFiannacca S1 aCosenza B1 aQuartarone A1 aCalabrò R00aThe Neurological Impact of Leprosy: Manifestations and Treatment Approaches.  uhttps://mdpi-res.com/d_attachment/neurolint/neurolint-16-00111/article_deploy/neurolint-16-00111.pdf?version=1731749677  a1492-15080 v163 a<p><strong>Background and Objectives: </strong>Leprosy primarily affects peripheral nerves, leading to significant neurological complications such as polyneuritis, mononeurosis, and autonomic dysfunction, which contribute to severe disabilities and impaired quality of life for patients. This scoping review aims to investigate the neurological manifestations and main treatments of leprosy patients.</p>

<p><strong>Materials and methods:&nbsp;</strong>Studies were identified from an online search of PubMed, Web of Science, Cochrane Library, Embase, and Scopus databases. This review has been registered on OSF (n) PQBYH.</p>

<p><strong>Results:&nbsp;</strong>Neurological complications of leprosy, such as neuropathy and paralysis, necessitate accurate diagnosis and treatment, as immunological reactions can exacerbate nerve damage. Various studies highlight the effectiveness of personalized therapies, such as corticosteroids, multi-drug therapy (MDT), and surgical interventions, in improving symptoms and neurological function in leprosy patients.</p>

<p><strong>Conclusions:&nbsp;</strong>Managing neurological complications of leprosy necessitates careful diagnosis and treatment, as many patients experience unresolved peripheral neuropathy despite multidrug therapy. Future research should focus on improving diagnostic tools, exploring the link between neuropathic pain and psychological issues, and developing effective vaccines and treatments to enhance patient outcomes.</p>
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