01580nas a2200217   4500000000100000008004100001260002200042653002500064653002400089653002500113653001100138100001000149700001200159700001200171245006400183856007000247300000800317490000700325520100500332022002501337       2024                            d  bSAGE Publications10aLucio’s phenomenon10alepromatous leprosy10aMycobacterium leprae10aCanada1 aYu AC1 aChan AR1 aChow EY00aLucio’s phenomenon in a non-endemic region: A case report  uhttps://journals.sagepub.com/doi/reader/10.1177/2050313X241304881  a1-40 v123 a<jats:p> Leprosy remains a persistent health challenge in endemic regions with cases rising in non-endemic regions such as North America. Patients with leprosy present with a variety of symptoms including limited skin lesions in tuberculoid leprosy to extensive lesions and high bacterial proliferation in lepromatous leprosy. This case report details a 77-year-old Canadian man of South Asian descent with lepromatous leprosy and Lucio’s phenomenon in Western Canada. The patient exhibited widespread retiform purpura on the limbs with localized ulcerations, erosions, and necrosis on the left hand and feet, peripheral neuropathy, and digit shortening. Histopathological examination and PCR confirmed Mycobacterium leprae. Management involved a 24-month multidrug therapy, leading to significant symptom reduction. This report highlights the diagnostic challenges of leprosy in non-endemic regions and the importance of a multidisciplinary approach for accurate diagnosis and treatment. </jats:p>  a2050-313X, 2050-313X