02124nas a2200265   4500000000100000008004100001260001200042653001200054653001500066653002000081653002400101653001800125653002600143653002500169653002700194653001700221653001000238100002200248700001400270700002300284245009300307856026000400300000900660520118900669       2024                            d  bMDPI AG10aleprosy10aneuropathy10aneuroimmunology10asocial implications10amycobacterium10aperipheral neuropathy10aautonomic neuropathy10asmall fiber neuropathy10aganglionitis10alepra1 aPitton Rissardo J1 aByroju VV1 aFornari Caprara AL00aExploring The Neurological Manifestations of Leprosy: Clinical Insights and Implications  uhttps://www.researchgate.net/profile/Jamir-Pitton-Rissardo/publication/386997205_Exploring_The_Neurological_Manifestations_of_Leprosy_Clinical_Insights_and_Implications/links/67602f881da39f149578a8dc/Exploring-The-Neurological-Manifestations-of-Leprosy-Cl  a1-193 a<jats:p>Leprosy is one of the neglected tropical diseases, and its elimination is a public health problem globally. This manuscript comprehensively explores the neurological manifestations of leprosy, offering clinical insights and implications for diagnosis, management, and understanding of the disease. Beginning with a review of historical context, etiology, and epidemiology, we delve into the pathophysiology of leprosy neuropathy, highlighting mechanisms of nerve damage and immune response. Peripheral nerve involvement, including sensory and motor deficits, nerve enlargement, and deformities, is discussed in detail, along with challenges in diagnosis and management. Psychological and social implications of neurological deficits in leprosy are addressed, emphasizing the importance of holistic care and support. Emerging neuroimaging and molecular diagnostics trends offer promising avenues for improved diagnosis and therapeutic interventions. Novel therapeutic strategies are identified to enhance treatment efficacy and prevent disability in leprosy neuropathy by targeting immunomodulatory pathways, antibacterial agents, and personalized medicine approaches.</jats:p>