01832nas a2200193   4500000000100000008004100001653001600042653001200058653001400070653001900084653000900103100001200112700001500124700001200139245006000151856006800211300001200279520134700291       2024                            d10aSarcoidosis10aLeprosy10aGranuloma10aCorticosteroid10aPUVA1 aPatil R1 aMarfatia Y1 aPatel B00aCutaneous Sarcoidosis Treated as Leprosy- A Case Report  uhttps://www.ijl.org.in/published-articles/28122024074520/11.pdf  a343-3473 a<p>Sarcoidosis is a multisystem disease of unknown aetiology characterized by epithelial cell granulomas without caseation in different organs. It involves mainly the mediastinal and peripheral lymph nodes, lungs, skin, eyes, liver and spleen. It acts as a great mimicker of various skin and systemic diseases. Diagnosis is challenging and mainly done by exclusion. Histopathology shows well-formed naked epithelioid cell granulomas and inclusion bodies. Corticosteroids are the mainstay of treatment. Herein we report a 60-year-old male, who presented with asymptomatic multiple erythematous well-defined plaques over face, trunk and upper limb clinically looking like lepromatous leprosy. He was earlier treated with anti-leprosy drugs (ALD) for 6 months as facilities for slit-skin smears and biopsy were not available at that time, following which he showed no improvement. There was no motor/ sensory deficit and skin smear for acid-fast bacilli (AFB) was negative. Skin biopsy was taken from a representative lesion. Histopathological findings were suggestive of sarcoidosis. He then started oral and topical corticosteroids along with PUVA therapy, following which he showed significant improvement. This report highlights the need to access to slit-skin smears and histopathology to confirm or rule out the diagnosis of leprosy.</p>