01875nas a2200229   4500000000100000008004100001260004400042100001400086700002200100700001400122700002300136700001400159700001700173700001400190700001400204700001200218700001700230245009300247856009200340520119900432022001401631       2025                            d  bSpringer Science and Business Media LLC1 aRashidi M1 aPitton Rissardo J1 aByroju VV1 aFornari Caprara AL1 aRashidi F1 aPrathiraja O1 aMoharam H1 aElendu CC1 aBahar M1 aJayasinghe M00aExploring the Neurological Manifestations of Leprosy: Clinical Insights and Implications  uhttps://assets.cureus.com/uploads/review_article/pdf/335410/20250122-3078247-ozrr5m.pdf3 a<p>Leprosy is one of the neglected tropical diseases, and its elimination remains a public health problem globally. This manuscript comprehensively explores the neurological manifestations of leprosy, offering clinical insights and implications for the diagnosis, management, and understanding of this disease. Beginning with a review of historical context, etiology, and epidemiology, we delve into the pathophysiology of leprosy neuropathy, highlighting mechanisms of nerve damage and immune response. Peripheral nerve involvement, including sensory and motor deficits, nerve enlargement, and deformities, are discussed in detail, along with the challenges in diagnosis and management. Psychological and social implications of neurological deficits in leprosy are addressed, emphasizing the importance of holistic care and support. Emerging trends in neuroimaging and molecular diagnostics offer promising avenues for improved diagnosis and therapeutic interventions. Novel therapeutic strategies are identified to enhance treatment efficacy and prevent disability in leprosy neuropathy by targeting immunomodulatory pathways, antibacterial agents, and a personalized medicine approach.</p>
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