01705nas a2200349   4500000000100000008004100001260001300042653001200055653002400067653002700091653001100118653001100129653002400140653001200164653002600176653001900202653000900221653001400230653002500244653001800269653003000287100001300317700001500330700001600345700001500361245012500376856009000501300001000591490000700601520073300608022001401341       1987                            d  c1987 Jan10aAnimals10aAntigens, Bacterial10aChemical Fractionation10aFemale10aHumans10aIn Vitro Techniques10aleprosy10aLymphocyte Activation10aMacaca mulatta10aMale10aMonocytes10aMycobacterium leprae10aReceptors, Fc10aT-Lymphocytes, Regulatory1 aOhkawa S1 aMartin L N1 aFukunishi Y1 aGormus B J00aRegulatory role of FcR+ and FcR- monocyte subsets in Mycobacterium leprae-induced lymphoproliferative response in vitro.  uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC1542573/pdf/clinexpimmunol00112-0052.pdf  a43-500 v673 a<p>We investigated nine rhesus monkeys (Macaca mulatta) inoculated with Mycobacterium leprae and three normal human contacts. Peripheral blood monocytes were separated into Fc receptor positive (FcR+) and Fc receptor negative (FcR-) fractions, and their regulatory role in the lymphoproliferative response in vitro to M. leprae was studied. FcR- monocytes had strong antigen presentation activity and produced no suppressor effect while FcR+ monocytes had weak antigen presentation activity and produced a non-specific suppressor factor spontaneously. With this assay system we determined that M. leprae-inoculated rhesus monkeys could be divided into three groups: good responders, very weak responders, and non-responders.</p>  a0009-9104