01319nas a2200241   4500000000100000008004100001260000900042653001100051653002300062653001200085653001600097653001800113653001700131100001500148700001100163700001300174700001500187245010500202300001200307490000700319520073700326022001401063       1988                            d  c198810aHumans10aImmunity, Cellular10aleprosy10aMiddle Aged10aT-Lymphocytes10aTheophylline1 aBottasso O1 aPuig N1 aAmerio N1 aMorini J C00a[Study of T lymphocyte subpopulations in patients with leprosy, using incubation with theophylline].  a397-4010 v163 a<p>T cells and the theophylline resistant cells (the-r, helper cells) in peripheral blood of patients with different forms of leprosy were studied. Active lepromatous patients (LL+) showed a significant decrease in T lymphocytes and the-r cells. Nevertheless, in LL+ developing a reactional episode of erythema nodosum (LL-ENL) a restoration in the level of the-r cells was observed. It is concluded that in LL+ patients the depression of T cells and the-r cells represents an imbalance in the T-T cellular cooperation with a defective cellular immune response. On the other hand, the recovery of the-r cells in LL-ENL support the hypothesis of a cell mediated immune mechanism in the immunopathology of this reactional episode.</p>  a0210-5187