01558nas a2200337   4500000000100000008004100001260001300042653001000055653001100065653001900076653002000095653002000115653004100135653001100176653001200187653000900199653001300208100001300221700001100234700001500245700001500260700001200275700001300287700001200300700001700312245008500329300001000414490000700424520077500431022001401206       1985                            d  c1985 Oct10aAdult10aFemale10aGene Frequency10aHLA-DQ Antigens10aHLA-DR2 Antigen10aHistocompatibility Antigens Class II10aHumans10aleprosy10aMale10aThailand1 aSchauf V1 aRyan S1 aScollard D1 aJonasson O1 aBrown A1 aNelson K1 aSmith T1 aVithayasai V00aLeprosy associated with HLA-DR2 and DQw1 in the population of northern Thailand.  a243-70 v263 a<p>A study of the frequency of HLA-DR2 and DQw1 was performed in leprosy patients and controls in northern Thailand. HLA-DR2 was found in 100% (17/17) of patients with sporadic tuberculoid leprosy and in over 90% (30/32) of all tuberculoid leprosy patients, as compared to 62% (20/32) of controls (p = .02). These strong associations had relative risks of 21.4 for sporadic and 7.4 for all tuberculoid leprosy, and etiologic fractions of 1.0 and 0.84, respectively. There was also a statistically significant and strong association between tuberculoid leprosy and DQw1. These data add to the growing body of evidence that products of HLA class II determinants or closely linked genes may play a role in determining the clinical manifestations of M. leprae infection.</p>  a0001-2815