01500nas a2200325   4500000000100000008004100001260001300042653001200055653002000067653002700087653002700114653001200141653002000153653002500173653002200198100001500220700001500235700001500250700001300265700001800278700001300296700001400309700001500323700001600338245011000354300001100464490000700475520067800482022001401160       1987                            d  c1987 Sep10aAnimals10aCercopithecidae10aCercopithecus aethiops10aDisease Models, Animal10aleprosy10aMonkey Diseases10aMycobacterium leprae10aPeripheral nerves1 aBaskin G B1 aGormus B J1 aMartin L N1 aWolf R H1 aBlanchard J L1 aMalaty R1 aWalsh G P1 aMeyers W M1 aBinford C H00aExperimental leprosy in African green monkeys (Cercopithecus aethiops): a model for polyneuritic leprosy.  a385-910 v373 a<p>Three African green monkeys (Cercopithecus aethiops) were inoculated intravenously and intracutaneously with Mycobacterium leprae derived from a naturally infected mangabey monkey. All developed cutaneous lesions at inoculation sites. One developed disseminated cutaneous lesions, while the cutaneous lesions in the other two regressed and eventually disappeared. The animals were examined at necropsy five years after inoculation. All three had active leprosy infection in peripheral nerves with extensive inflammation and fibrosis. The disease histologically resembled borderline-lepromatous leprosy. These findings add a new dimension to animal models of leprosy.</p>  a0002-9637