01165nas a2200301   4500000000100000008004100001260001300042653001200055653002600067653001400093653001500107653001900122653001100141653001200152653001600164653000900180653002500189653001600214100001600230700002300246700001500269700001300284245007900297300001000376490000700386520045600393022001400849       1987                            d  c1987 Jun10aAnimals10aAnti-Bacterial Agents10aCefoxitin10aCefuroxime10aCephalosporins10aFemale10aleprosy10aMezlocillin10aMice10aMycobacterium leprae10aPenicillins1 aShepard C C1 aVan Landingham R M1 aWalker L L1 aGood R C00aActivity of selected beta-lactam antibiotics against Mycobacterium leprae.  a322-70 v553 a<p>Twelve beta-lactam antibiotics were tested for activity against Mycobacterium leprae growing in the foot pads of mice. Two cephalosporins (7-aminocephalosporanic acid and cefuroxime) and one cephamycin (cefoxitin) showed significant activity against M. leprae, and one penicillin (mezlocillin) exerted possible growth-promoting activity. These results suggest that particular molecular structures may be required for activity against M. leprae.</p>  a0148-916X