01511nas a2200373   4500000000100000008004100001260001300042653001000055653000900065653001400074653001000088653002100098653001100119653001100130653001700141653000900158653002500167653001600192653002900208653004500237653001300282653003200295653001500327653000900342653003000351653001500381100001300396700001400409245005500423300001200478490000700490520062600497022001401123       1985                            d  c1985 Oct10aAdult10aAged10aAustralia10aChild10aChild, Preschool10aFemale10aHumans10aInflammation10aMale10aMicroscopy, Electron10aMiddle Aged10aMycobacterium Infections10aMycobacterium Infections, Nontuberculous10aNecrosis10aNontuberculous Mycobacteria10aRecurrence10aSkin10aSkin Diseases, Infectious10aSkin Ulcer1 aHayman J1 aMcQueen A00aThe pathology of Mycobacterium ulcerans infection.  a594-6000 v173 a<p>The pathology of cutaneous ulcers resulting from Mycobacterium ulcerans infection is reviewed. Initial infection causes ulceration with necrosis of the dermis and a septate panniculitis in subcutaneous fat. There is little cellular reaction despite the presence of large numbers of organisms. Recurrent or persistent infection produces a granulomatous reaction with epithelioid macrophages, variable numbers of giant cells of the Langhans type, and relatively few organisms. This type of reaction is associated with more successful treatment of the disease and appears analogous to the tuberculoid form of leprosy.</p>  a0031-3025